Mission 01 System 02 Research 03 Impact 04 Careers 05 Filings 06 Contact 07
Stockholm, Sweden
Published application 202641026065
Synthetix Health · Research & Engineering Lab · Stockholm

The patients stay private. The medicine moves.

Synthetic clinical cohorts, made inside the hospital under formal differential privacy. Each one certified for what it can do, and what it can’t.

ε-DP

A mathematical ceiling on what any output reveals about one personFormal privacy bound

0

Raw patient records leaving the hospital, by designRaw records leave

CPI

Measured utility and contraindications on every releaseOn every release

PCT

Patent-pending synthesis architecture, published and filed internationallyFiled internationally

§ 01The problem

The medicine of the next twenty years will be learned from data that, today, cannot legally move.

01 / Locked

Records stay behind walls.

Clinical data sits inside hospitals, regions and national borders. Every research question begins with months of agreements before a single analysis runs.

02 / Leaky

De-identification is a hope, not a proof.

Removing names and dates leaves people re-identifiable by what remains. It offers no bound on what an output reveals about any one patient.

03 / Unlabelled

Synthetic data ships without a label.

Generation alone is not privacy. Models can memorise rare records, and most synthetic data is released without saying what it is safe to use for.

§ 02Thesis

Medicine became trustworthy when it was made to a standard. Health data has to follow.

The prescription put a standard between the compound and the patient. Made to spec, labelled honestly, traceable end to end. Sx is that standard for health data.

01

Manufactured to a standard.

Every cohort is generated under formal ε-differential privacy, a mathematical ceiling on what the output can reveal about any one person. It is stated as a number, not a promise.

02

Labelled honestly.

Each dataset carries a Clinical Privacy Index certificate with its privacy budget, measured utility, and printed contraindications, the uses it is not fit for.

03

Traceable end to end.

Every operation is written to a hash-chained audit trail that an auditor holding the log can recompute. Trust is verified, not asserted.

§ 03The certificate

Every dataset carries its own proof.

The Clinical Privacy Index is a clear verdict for a decision-maker and a full specification for an auditor. It says how private a dataset is, how faithful it is, and what it must not be used for.

A certificate that only lists strengths is marketing. Ours prints contraindications, the way a medicine prints side effects.

Clinical Privacy IndexSX-SAMPLE-SYNPUF-001Sample
ε 1.0
Person-level differential privacy · δ = 10⁻⁵ · Rényi accounting
0.91
Mean marginal concordance · 7 / 7 OMOP links pass
DatasetOMOP CDM v5.3 format · 5 tables (core fields) · 5,000 persons · 1.85M event rows
Guarantee(ε = 1.0, δ = 10⁻⁵), add / remove one person across all tables
Linkage7 / 7 referential checks pass · 0 orphan rows
ContraindicatedPharmacovigilanceRare-disease cohortsPrimary regulatory evidenceTemporal sequence analysis
Marginal1 − Jensen–Shannon distance vs. seed
Visit type mix0.999
Sex0.996
Age distribution0.941
Procedure codes0.908
Diagnosis codes0.842
Drug codes (NDC)0.797
Composite0.91
PharmacovigilanceSafety signals live in rare events; privacy noise smooths exactly those.
Rare-disease cohortsSmall groups sit in the distribution tails that privacy smooths most.
Primary regulatory evidenceSuitable as secondary evidence only; not a substitute for source data.
Temporal sequence analysisIn this release, event dates are sampled uniformly within 2008–2010; visit intervals and sequences are not preserved.
Fit for (this release)OMOP pipeline and software validation · multi-table linkage testing · cohort-query prototyping
Entries10 recorded privacy-ledger operations
CompositionTotal privacy loss composes to (ε = 1.0, δ = 10⁻⁵); downstream synthesis is covered by the post-processing guarantee
Chain head4367151fe3c2e1814aceb3cf2d1e717f396707a76e610c2934c154ef27d33a21
VerificationAltering any entry breaks the chain on recomputation
Seed · public CMS DE-SynPUF benchmarkChain head 4367151f…7d33a21

A 5,000-person cohort synthesised across five linked OMOP CDM v5.3-format tables under person-level (ε = 1.0, δ = 10⁻⁵) differential privacy, seeded from the public CMS DE-SynPUF benchmark. It ships with its certificate, fidelity snapshot and linkage report. Shared with institutional addresses after review; no live patient records are involved.

§ 04System

From records that cannot move to certified data that can.

The engine runs where the data lives. Raw records stay inside the source institution; only certified synthetic cohorts cross the boundary.

Inside the source institution · raw records never leave

Inside the source institutionRaw records never leave
Stage 01

Ingest

Source data arrives as FHIR R4, HL7, CSV or a direct EHR export. Schemas are validated and mapped to standard clinical models inside the institution's own environment.

FHIR R4HL7OMOPCSV
Stage 02

Synthesise

The privacy engine generates new records on a single local GPU inside the hospital, under a formal differential-privacy guarantee tuned to a stated privacy–utility target. Clinical signal is preserved within a measured utility bound; individual disclosure is capped by (ε, δ).

ε-DPGenerative modelsEdge-deployedSingle GPU
Stage 03

Certify

Each output is measured and issued a Clinical Privacy Index certificate. It states privacy strength, clinical utility, regulatory readiness per jurisdiction and contraindications.

CPI scoreUtility gradeContraindications
Research & ML environmentCertified cohorts only
Stage 04

Deploy

Certified cohorts export to research and machine-learning pipelines through a standard API. Every release is recorded in the audit trail, so the full history can be checked later.

REST APIPyTorchAudit trail
Published applicationIN 202641026065 · expedited examination
InternationalPCT/IN2026/051623
PipelineFurther filings in progress
StandardsFHIR R4 · OMOP CDM
FootprintA single on-premise GPU
Filings →
§ 05Impact

Our impact and our revenue are the same unit.

Every certified cohort unblocks research that would otherwise wait months for a data agreement. We will report every release and its measured impact annually.

Access

Unlock cohorts that cannot move.

Research that waits months for a data agreement can start from a certified cohort instead.

SDG 3.b
Inclusion

Bring absent populations into research.

Institutions and regions missing from global datasets can contribute without their records ever leaving.

SDG 9.5
Proof

Make patient privacy a mathematical bound, not a policy promise.

Protection stated as a bound with a method behind it, not a promise in a data-sharing agreement.

SDG 16.10
§ 06Research

Synthetic health data, taken seriously.

We publish on formal privacy, European regulation and evaluation, including where synthetic data fails.

Policy & regulation briefs
Technical notes
TN-01 · In preparation

Referential integrity under person-level differential privacy

Auditing orphan rates and cross-table structure in multi-table OMOP synthesis.

TN-02 · Published 2 Nov 2026

Formal privacy costs the smallest groups most

Measured on our own public release across 24 subgroups, with a random sample as control, and what a certificate must therefore say.

TN-03 · In preparation

Membership-inference audits against stated bounds

Testing empirical leakage against the claimed (ε, δ) on public claims data.

§ 07Join the lab

A small team, setting the standard.

Founded in Stockholm by Gaurav Raj Chattarki, sole inventor on the published application. We are assembling a founding team of researchers and engineers who want their work to be provable and used in medicine.

gaurav@synthetixhealth.com →

Work with us.

Tell us about your data, your constraints, or the question you are trying to answer.

Research & dataHospitals, registries, life sciences
InvestorsImpact and deep-tech funds
TalentFounding roles & thesis students

No mailing lists. Processed under our privacy policy.